The Unmet Need

Nearly 4 million people are diagnosed each year with cartilage damage in the U.S. alone. Of which, almost half undergo procedures related to tear of cartilage in the knee. Articular cartilage damage can be the result of sudden injury, or part of a long-term degenerative process. Symptoms may include pain to the joint, swelling, disability and progressive restriction of motion. If left untreated, cartilage damage may result in osteoarthritis.

Articular cartilage is a unique form of cartilage that serves a major function in the reduction of friction at joints and enables movement. It bears weight and can withstand enormous pressures. However, in adults articular cartilage has limited regenerative capacity, which prevents its spontaneous healing after traumatic injuries. Natural response to damaged articular cartilage is scar tissue formation which simply lacks the unique biophysical attributes of this cartilage.